A Simple Enzyme That May Add to a Patient’s Estogenic Overload
Posted on April 23rd, 2017That simple enzyme that can induce catastrophic diseases for patients is called aromatase.
According to Wikipedia, aromatase is an adrenal enzyme.
It is also called estrogen synthetase or estrogen synthate.
Aromatase has the ability to transform androstenedion into estrone and testosterone into estradiol.
Aromatase is therefore responsible for aromatization of androgens into estrogens.
This enzyme can be found in many different types of tissue. Including the following:
. Gonadal granulose cells
. Brain tissue
. Adipose tissue
. Blood vessels
. Bone
. Skin
. Endometrial tissue
. Uterine fibroids
. Breast cancer
. Endometrial cancer
Many scientific investigators have also found that elevated amounts of aromatase in young children can cause medical problems.
In young boys, an excess of aromatase can cause gynecomastia.
In young girls, an excess of aromatase can lead to precocious puberty and gigantomastia.
In adults, what can lead to the production of excess aromatase?
The following are the main causes.
. Age
. Obesity
. Insulin
, Alcohol
. Gonadotrophins
In certain instances you can begin to see the problems that excessive amounts of aromatase can cause.
Aromatase inhibitors are commonly used to treat breast cancer.
Experiments have indicated that normal tissue in a Petri dish when exposed to estrogen, will grow out of control.
As you already know, excessive amounts of estrogen can be very harmful medically.
If you consider any type of allergy, autoimmunity and cancer, there must be a concern about the presence of excessive amounts of aromatase creating too much estrogen.
Even with an endocrine immune imbalance and the production of excessive amounts of adrenal estrogen, excessive amounts of adrenal androgen produced and what we know about aromatase, there must be a concern that the excess adrenal androgen will be turned into more estrogen and cause allergy, autoimmunity, cancer or even worse.
An awareness must be present when a male takes a male enhancing drug or hormone like testosterone, because that supplement can be turned into estrogen by the aromatase.
Many overweight patients, with normal thyroid hormone levels, may have an endocrine immune imbalance which is causing the production of elevated amounts of adrenal estrogen and androgen.
The elevated amounts of adrenal estrogen are problematic enough without having to also worry about the aromatase turning the adrenal androgen into more damaging estrogen.
Unfortunately, I have not found any literature yet, that determines what an aromatase level should be in a human or in an animal.
My suggestion for helping to determine if you or your pet are producing too much aromatase, would be to measure estradiol, estrone, estriole and adrenal estrogen and adrenal androgen.
Adrenal estrogen at this time is recognized and measured as total estrogen.
LabCorp and Quest laboratories can do total estrogens for you and National Veterinary Diagnostic Services can do adrenal estrogen for your canine, feline or equine.
If your health care professional is concerned that you are producing an excessive of aromatase, they may recommend the use of an aromatase inhibitor.
An aromatase inhibitor is used specifically to block the aromatase enzyme.
The medical literature indicates that when an aromatase inhibitor is used, it means that less estrogen is available to stimulate the growth of hormone receptor-positive breast cancer cells and also other responsive cancer cells.
The following is a list of commonly used aromatase inhibitors;
. Femera
. Arimidex
. Aromasin
. Tesilac
. Resveratrol
. Vitamin E
. Zinc
Hopefully this article will help you better understand aromatase, and also help you live a healthier, longer life for both you and your pet.
Sincerely,
Dr. AL Plechner
