Sudden Acquired Retinal Degeneration Syndrome (SARDS)
Posted on April 3rd, 2013This post was originally published in Nutricula Magazine on February 8th, 2013
The entire world is beginning to find a definite increase in SARDS, a hormone antibody imbalance which leads to blindness, and even worse, may progress into allergies, autoimmunity and cancer.
Often this developmental blindness will not be realized by the pet’s owner before total retinal damaged has occurred.
This is a very difficult disease to diagnose in general practice because a special electrogram needs to be done on the patient’s retina for a positive diagnosis, and this diagnosis usually needs to be performed by a veterinary ophthalmologist.
The cause of SARDS seems to still be somewhat of a mystery to the veterinary profession. My own clinical studies of SARDS classifies it as an autoimmune disease caused by a deregulation of the immune system and the immune cells losing recognition of self-tissue, including that of the retina.
Once SARDS has been diagnosed, it is vitally important to have your veterinarian do a special endocrine immune blood test to help correct this imbalance and stop this abnormal immune response before the patient’s retinal tissue is permanently damaged.
Once tested, these SARDS patients all have deficient, bound or elevated, defective cortisol which is produced from the middle layer of the adrenal cortex.
NOTE: Cortisol is a daily, natural hormone in people and animals that if not produced in proper amounts or is defective, will lead to allergies and autoimmunity, including SARDS and cancer. This deficient or damaged cortisol is not recognized by the patient’s pituitary gland and cannot fulfill it negative feedback mechanism for the body.
The excess production of the pituitary hormone ACTH, causes the inner layer of the adrenal cortex to produce elevated amounts of adrenal estrogen and acts as a direct feedback for the body.
Once this has occurred, the elevated total estrogen deregulates the immune system so that the B and T lymphocytes no longer provide their protection for the patient’s body. These lymphocytes are now deregulated to the point where they lose recognition of self-tissue. This causes them to produce anti-antibodies create a cell mediated damage to various tissues in the body and with SARDS, that tissue is retinal (tissue).
The elevated estrogen binds to the receptor sites of the thyroid hormone, and at the same time, causes the B cell production of protective antibody to deplete.
When this occurs, the mucous membrane in the eye (and the rest of the body), referred to as immunoglobulin A (IgA), is deficient and can allow for further loss of protection in the eye and in the rest of the body.
When the IgA level drops below a certain point, even if proper hormone supplementation is done orally, the patients usually will not be able to absorb the hormone supplement through the intestinal wall. This is why, when a patient is in the hospital on IV medication and is sent home on the same medication, it does not work as well if at all.
Often new oral medication may be prescribed, but if the patients IgA level is not increased, that medication will also not be absorbed.
I do have further information on SARDS on my website at www.drplechner.com including the test and correct laboratory to send the blood sample.
I am also available for consultation if needed. These are only my thoughts, and I hope they help.
NOTE - It is vital with any suspected autoimmune disease, not to use any medications or supplements that contain Sulfa, Melatonin, Rozerem or Echinacea. It has been recognized, that compounds containing Sulfa may alter the surface the red blood cell and cause an autoimmune hemolytic anemia and the other three supplements may cause an increased stimulation of an already deregulated immune system and worsen the patients disease.
To: Dr. Alfred Plechner
Our 10 yr. old days hound just lost his sight. We just took him to vet because of increased weight gain. Checkup and blood work o.k. Research suggests possibly SARDS. Wife upset Swoop like her child. Understand univ. Of Iowa has done some extensive research and you seem to be top authority on subject. Thank you, Joe
Dear Dr. Plechner,
being a vet I came across your blog and would like to get some further information about your ideas. As the perception of sight is now very precise by the owner ( as one of the obove writers mentions, the dog sees the hand in front of the nose probably has nothing to do with vision), I think one of the most reliable test to determine sight would be an ERG. Have you done ERG before and after treatment in cases of SARDS and see any significant inprovements. If so, would you publish them ?
Thanks for your reply
Mat
Hi Mat,
I did send you an e-mail.
Let’s talk.
AL
I wanted to know if you have quantified the number of dogs you have treated for SARDS and determined the percentage that have been successfully treated. Just trying to get an idea what the success rate of your program is.
Scott
Hi Scott, I have treated close to 60 SARDS cases and probably many more, because many cases are being treated by other veterinarians I consult for with their first few cases until they can treat the cases themselves with my protocol. If I can get a case started early, and the owner has not noticed the dogs blindness after too much time, I am getting about a 65% to 70 % return of some sort of vision. Early on, the vision is for far sight and as time passes, often complete vision does return.
Since this is an autoimmune disease, what is even more important than even the sight returning, is correcting the cause of SARDS, and stopping the further development of other autoimmune diseases and cancer.
Hopefully the day will come when I can interest one of the veterinary universities in my findings and help with proper SARDS therapy.
I hope I have answered you question.
Sincerely,
Dr. AL Plechner
My11 year old Sharpei was diagnosed with SARDS on October 14, 2013. She also had a CT/ultrasound and her adrenal glands were enlarged. An ACTH test was done and sent to UTK. The vet at UGA has prescribed Vetoryl and I can’t understand why. All the hormones that were High, Vetoryl states will raise those levels. Her cortisol was Normal and Vetoryl will lower that. I’m scared that this isn’t the medicine she needs. Can someone help me?? Please….
Hi Donna,
Me again. I do have a protocol which is a simple blood test that is different from all other blood tests, but possibly could make some heads and tails out of the blood test which were done.
These are just some of my thoughts.
Have a good evening.
AL
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Very interesting.
Thank you for your comment.
Sincerely,
Dr. AL Plechner
+
I am in the same case as Edward L Parker.
all the examinations of Billou give normal results
Hello,
Could you communicate the address to me E e-mail of Edward L Packer or communicate mine to him?
goal: to exchange our unhappy hope and our hopes.thank you
hello,
My dog Billou (poodle of 7ans) has just lost the sight on May 7th, 2013.
An examination makes in PARIS on June 7th, 2013, the electroretinogram, diagnosed us the sudden acquired retinal degeneration.
by using products ANIMIN and ASTAXATHIN, can its sight be restored?
if so, where does one buy these products? and which is the amount to be taken for a dog of 11kg?
Thank you in advance
and Hello of FRANCE
bonjour,
Mon chien Billou (caniche de 7ans) vient de perdre la vue le 7 mai 2013.
Un examen fait à PARIS le 07 juin 2013, l’electrorétinogramme, nous a diagnostiqué le sudden acquired retinal degeneration.
Existe-t-il un traitement pour combattre cette cécité ?
merci d’avance
I am sorry I do not speak French, but if I understand a little bit, you have SARDS dog that needs help.
SARDS is definitely treatable and needs to be done as quickly as possible in hopes of restoring sight and stopping any other catastrophic disease from happening like autoimmunity and cancer.
Please read about the treatment for SARDS on this website.
I hope this helps.
Sincerely,
Dr. AL Plechner
Hopefully the information will let people with SARDS animals know there is a cause and a definite treatment.
Sincerely,
Dr. AL
Dr Plechner, my boy recently started back in March with the blindness.I took him to Purdue IN for neuro followup since they performed disc surgery last year in his neck region. He was pretty much paralyzed and on prednisone for several months before I finally took him to another vet for second opinion and that is when we were able to get the surgery done. He flat lined ERG although I tried to explain to them that he can see sometimes. It would come and go with his hearing. They assured me he was blind and no quality of life will be lost. Well now I can say that he is now pretty much all blind except sometimes he can see my hand directly in front of his nose. I had ACTH test done and sent to Tennessee. He is high in cortisol, androstendedione, estradiol, progesterone, 17 O Progesterone and post ACTH he was high is all and also Aldosterone. Aldosterone was normol before the injection. Post ACTH results – Cortisol(362) Androstendedione(9.81), Estradiol(89.3), Progesterone(3.46), 17 OH Progesterone(7.78) and Aldosterone (430.2). They put him on HMR lignan & meletonin. Will this help him? Will this bring back his eyesight. Prior to testing at Purdue he was found to have high liver counts so he is on liver meds. The Sono showed mottled pancrease and mineralized bile duct. He does have a spot on his liver but they didnt do anything with it because he had it last year when he was there for his disc surgury and they said it hasnt changed. They did MRI of brain this time and found nothing. The sono according to them did not show any abnormal looking adrenals. He is is good spirits and his personality has not changed at all. He is on thyroid medicine(soloxine) and as been for about 5 years. He was also on heart medicine(vetmedin and lasix) until last year due to Purdue not finding anything to warrant the heart medicine. My previous vet had him on the heart meds for two years and last year the new vet nor Purdue neither noticed and enlarged heart or heart murmer. Purdue did the EKG and I think MRI and other heart evaluations and found that he was not in heart failure so they took him off the heart meds. WIth all his issues, I am not sure what meds he could be on for this current condition but do you think the melatonin and lignan will help him or is there something else that he should be treated with.
Hopefully my reply came through.
If not, please contact me and I can show you how to treat SARDS.
AL
I need help..is this Al I’m talking to? 1 yr ago my dog (old English, approx. 10yrs)became incontinent. She was treated with meds, one of which was incurin which I understand supplements oestrogen to restore bladder control. this worked for approx. 2 weeks, then failed, so I decided to stop the drug. I decided to try it again, and after a while, with no real success, I stopped it again and decided the mop and bucket was best. couple of months ago I noticed she was stumbling occasionally and she has now gone blind. she has been diagnosed with probable cushings and for almost a month has been on vetoryl. the vet who prescribed this for some reason did not test her after the 10 day period, and left her on this.. I changed vets and they say the bloods are much worse than the first vet’s results. not yet rcd back the results to monitor the effects of the vetoryl, will get those today..
could the incurin/oestrogen increase have caused/exacerbated this? She is due to go in today for the definitive test for sards, elecro something…and abdo scan but she is getting worse and euthanasia seems the kinder option. I want to stop the vetoryl… why are the bloods much worse, is vetroyl making her worse? think I will stop it. my other dog is on leventa for hypothyroidism, I feel I want to give her some of this after my readings on the internet but am afraid to do this or go against current vet’s advice, which will no doubt be to increase vetoryl! Heeeelp. thanks.
Dear Dr. Plechner, our 9 year old female Westie was diagnosised, early April 2013, with SARD’s. Testing and evaluation was done by Michigan State University Vet School Opthomolgy Department. A retina scan flat lined. She is completely blind.
We had a battery of blood chemitries done which all came back within normal limits. Her Urine Creatinine Cortisol test was negative.
Are we at the end of the treatment trail?
Dr. Plechner:
My mixed breed spaniel was diagnosed with SARDS 8/2009. That fall, he started the treatment regimen recommended by Caroline Levin and has continued since then with daily Medrol and Thyroxine.
Within weeks of the therapy, his vision returned but eventually waned and is now completely gone. Despite this, has done remarkable well until this past summer when he became more confused and a bit withdrawn. The general confusion has seemed to settle in despite attempts to kick start things by pulsing the Medrol.
My question is this. Is dementia a common finding with progression of the disease? I appreciate any feedback you may have on this. Ellen
Normally, if the endocrine immune blood levels remain normal, the regained sight should continue and secondary effects should not occur.
Unfortunately due to various inputs including aging and environmental changes, a yearly endocrine immune test is indicated so that if there are any changes they can be corrected before bad effects again occur.
Sincerely,
Dr. AL Plechner