Whit is the Cause of Autoimmunity and Cancer in Animals and Humans?

Posted on May 20th, 2017

There is so much information known about treating the effects of autoimmunity and cancer in animals and in humans, and definite thoughts about why these diseases occur, but no real measurable cause.

Over the past 50 years of practice, I have discovered an endocrine immune imbalance that seems to be the cause of autoimmunity and cancer in animals and in humans.

However this is definitely not to say that radiation, chemotherapy and excision should not be utilized.

The endocrine immune imbalance that I have found with all the cases of autoimmunity and cancer seems quite clear.

This occurs due to an endocrine mechanism that becomes imbalanced and allows for a deregulated immune system to develop.

Unfortunately, this may cause the patient to develop various kinds of diseases due to a lack of resistance to bacteria, viruses, molds and fungi.

The mechanism that is involved is as follows:

It begins with a deficient, bound, or defective cortisol, which is produced by the middle layer adrenal cortex, referred to as the Zona Fasciculata.

Normally an active amount of cortisol will regulate the immune system and fund its other functions that are also important for the body.

A normal sequence determines that the active cortisol to broken down by the liver and excreted by the kidneys.

This sequence initiates a negative feedback mechanism to the hypothalamus, which intern releases its hormone, referred to a Corticotropin-Releasing Factor (CRF).

The CRF causes the pituitary gland to release its hormone, referred to as Adrenocorticotropic Hormone (ACTH).

The ACTH release causes the middle layer adrenal cortex to release more active cortisol.

This entire sequence is referred to as a negative feedback mechanism.

Unfortunately when the cortisol is deficient, defective or bound, any imbalanced cortisol that is released will not fund the negative feedback mechanism.

When this situation is present, and the negative feedback mechanism cannot be funded correctly, and the release of CRF and ACTH will continue until the inner layer adrenal cortex responds in a direct feedback mechanism, producing elevated amounts of adrenal estrogen and androgen.

The inner layer adrenal cortex is referred to as the Zona Reticularis.

NOTE: This article will not discuss the adverse effects that are caused by elevated amounts of adrenal androgen.

When this cortisol imbalance is present, and the production of adrenal estrogen is elevated, what are the effects that the elevated adrenal estrogen will cause?

The following is a list of what the elevated adrenal estrogen will cause:


  • The elevated adrenal estrogen, when exposed to normal tissue in a Petri dish, will cause increased growth of that tissue.
  • The elevated adrenal estrogen will bind the receptor sites for the thyroid hormones and may induce a state of metabolic hypothyroidism.

NOTE: The cortisol imbalance will also reduce the transference of

 T4 (Thyroxin) into T3 (Triiodothyronine).

  • The elevated adrenal estrogen will deregulate the immune system and the B and T- lymphocytes will be unable to perform their protective functions for the patient. This may be one of the main causes for why a patient suffers from chronic, bacterial, viral, mold and fungal infections.

NOTE: From cases of a chronic viral disease, I have proven this to be the case with feline patients with FIV, which also seems to be the same with HIV.

Depending on how severe the endocrine immune imbalance is, will determine if the HIV will develop into AIDS. This may be the reason why a patient can be positive for HIV and never develop AIDS.

  • The elevated adrenal estrogen will also cause the B lymphocytes to reduce their production of immunoglobulins (antibodies) and when the mucous membrane antibody referred to as IgA, is present below a certain level, oral medications, supplements including replacement cortisol, will not be absorbed.

This is often why a hospitalized patient seems to do better when given medications intravenously or intramuscularly, but when they are sent home on oral replacement medication, due to a low IgA the patient cannot absorb the medication orally, and once again may begin to develop the original disease.

My clinical studies have indicated that the IgA levels that will cause malabsorption.

Those levels are as follows:

Canines and Felines = An IgA of less than 58 mg/dL will cause malabsorption.

Humans= An IgA of less than 68 mg/dL will cause malabsorption.

  • Elevated estrogen will cause an inflammation of the endothelial cells that line all the arteries in the body.

You can imagine all the disease ramifications that might happen due to this endothelial inflammation. Alzheimer’s’ syndrome?

Unfortunately to this date so far, adrenal estrogen and IgA levels are rarely measured.

If the adrenal estrogen is measured, it is usually measured as total estrogen and not recognized as being produced by the inner layer adrenal cortex (Zona Reticularis).

The estrogens that are normally measured only include estradiol, estrone and estriole and NOT adrenal estrogen.

Can you imagine if a patient begins to take a estrogen supplement based upon a low estradiol, when their adrenal estrogen is elevated?

Adding an estrogen supplement to an already elevated adrenal estrogen, will only add to the risk of developing an autoimmune disease or cancer.

I personally believe that one of the major causes for developing an autoimmune disease or cancer, may come from not understanding that this endocrine immune imbalance may exist.

The results for these endocrine immune values vary from laboratory to laboratory, whether for animals or for humans.

The following are the laboratories for animals and humans that seem to be the most accurate.

NOTE: The laboratories that have helped me create normal values over the past 50 years, includes Miles Laboratory, Veterinary Reference Laboratory, A and E Laboratories and NVDS.

The total number of endocrine immune mechanism blood tests that have been processed, are well over 100,000.

NVDS alone has done over 30,000 endocrine immune blood tests.

For animals, National Veterinary Diagnostic Services (NVDS) is the most accurate.

Their normal results are as follows:

. Cortisol = 1 to 2.5 ug/dL

. Adrenal or Total estrogen = 24.5 to 25 pg/dL

. T3 = 100 to 200 ng/dL

. T4 = 2 to 4.5 ng/dL

. IgA = 70 to 170 mg/dL

. IgM = 100 to 200 mg/dL

. IgG = 1000 to 200 mg/ dL

For humans, LabCorp seems to be the most accurate for attaining normal levels for my endocrine immune mechanism.

Their normal results are as follows:

. Cortisol = 5 to 20 ug/dL

. Total or Adrenal estrogen = 80 to 115 pg/dL

. Premenopausal =  Less than 40 pg/dl

. Postmenopausal = Less than 40 pg/dL

. T3 = 81 to 187 ng/dL

. T4 = 4.5 to 12 ng/dL.

. IgA = 70 to 312 mg/dL

. IgM = 56 to 352 mg/dL

. IgG = 639 to 1349 mg/dL

, Interleukin-6 (IL-6) = 5 to 15pg/ml

. Vitamin D = 20 to 100 ng/ml

          Conrad Lebeau suggested that Interleukin-6 and Vitamin D were

          also quite important to measure, because of the following.

          “IL-6 is a marker for an inflammatory immune response.

          In cancer and many other diseases, a high IL-6 level relates to a

          poor prognosis for recovering from cancer”.

          He also notes that hydrocortisone and its synthetic derivatives

          will suppresses IL-6, as will hot red peppers and hemp derived

          cannabinoids (CBD).

         “As Vitamin D levels rise to the upper quadrants (75 to 120 ng/ml)

         of their reference range, and IL-6 drops into the lower levels of its

         reference range, cancer should stop growing”. More information

         can be found on IL-6 in the Immune Restoration Handbook at


NOTE: it is very important to check with both of these laboratories if you are planning on having an endocrine immune mechanism blood test done, in order to make sure that these are still accurate, normal test levels and that the laboratory has not changed any of these listed, normal levels.

Hopefully this article might give you a better understanding, why autoimmune diseases and cancer may develop.

My hope is that this article might create some interest and a new direction for determining why these diseases and many other chronic diseases are occurring.

For further information on this mechanism, please go to this website www.drplechner.com and read an article titled “The Results of an International Convention for Integrative MD Oncologists, Regarding Dr. Plechner’s Findings for Many Different Chronic Human Diseases”.

Also on this website, you might also be interested in reading about my lectures from 14 years ago titled, ”Lectures Presented to the Broda Barnes MD Research Foundation”.


Dr. Al Plechner