My studies in canines, felines, equines and the 2,000 human patients that their health care professions allowed me become involved with all had elevated adrenal estrogen that the humans and veterinary laboratories measure as total estrogen.
My 90,000 endocrine immune blood studies were done on canines, felines and equines that already had their ovaries and testacies removed before the blood tests for total estrogen were completed.
Therefore in animals, adrenal estrogen may be measured mainly as total estrogen, which appears to be similar in humans, and LabCorp does provide a total estrogen test for humans, as well as do some other human laboratories.
National Veterinary Diagnostic Services is the only veterinary laboratory that can provide a total estrogen test for your canine, feline and equine..
Why does elevated adrenal estrogen occur?
It occurs due to a cortisol imbalance, which can happen either because of a cortisol deficiency or because of the production of a defective cortisol.
What is not understood yet is that the cortisol, which is produced by the middle layer adrenal cortex, can be normal or can even be elevated and not be recognized by the hypothalamic-pituitary axis in their negative feedback mechanism to the middle layer adrenal cortex, because the cortisol is defective.
When the adrenal cortisol is defective but elevated, often the medical profession considers this to be Cushing’s syndrome, which it is not, because the clinical symptoms and clinical signs are not typical for Cushing’s Syndrome and do not support a diagnosis for Cushing’s syndrome. This syndrome is than referred to as Atypical Cushing’s Syndrome and sometimes even Atypical Addison’s Syndrome.
In reality, I refer to this syndrome as ACEIS, which means Atypical Cortisol Estrogen Imbalance Syndrome, which deals with an elevated defective cortisol or a deficient cortisol.
This cortisol imbalance will lead to an elevated total estrogen, which is being produced by the inner layer adrenal cortex.
This occurs because the hypothalamic-pituitary axis do not recognize the defective cortisol or there is not enough cortisol to fund this negative feedback mechanism and when this happens, the hypothalamic-pituitary axis will continue to produce and release their hormones, CRF and ACTH, which will cause the middle layer adrenal cortex, to release more active cortisol if it can.
Because the middle layer adrenal cortex cannot fund this negative feedback mechanism, because of its production of deficient or defective cortisol, the inner layer adrenal cortex responds as a direct feedback, producing excess amounts of estrogen and androgen.
At this time, this paper will not discuss elevated adrenal androgen.
Unfortunately, providing a cortisol supplement to a patient at this time in medicine, whether for an animal or for human is thought to be risky, even in the face of identifying a deficient or defective cortisol.
I believe one of the reasons for these fears comes from the fact that when ongoing steroid supplementation is indicated a thyroid supplement also needs to be incorporated because of the elevated adrenal estrogen that the cortisol imbalance creates. The elevated adrenal estrogen disallows the patient’s body to use their thyroid hormones, and since the thyroid hormones cannot be used by the patient, any cortisol supplement will not be broken down by the liver and excreted by the kidneys in 24 hours. Because of this thyroid binding that the elevated estrogen may cause, the cortisol supplement will become an overdose, which may create all the clinical signs and symptoms that are accompanied by an overdose of cortisol.
Elevated adrenal cortex estrogen may cause the following medical problems:
- Elevated adrenal estrogen can cause an inflammation of the endothelial cells that line all the arteries in body. It makes me wonder if this may be part of the reason why Alzheimer’s Syndrome occurs due to the inflammation of the cerebral arteries. Also, I wonder if this inflammation of the endothelial cells are also responsible for coronary occlusion, caused by arteriosclerosis and atherosclerosis.
- Elevated adrenal estrogen will bind the availability of the thyroid hormones and may allow for the triiodothyronine (T3) and thyroxin (T4) to be within the normal range, but unavailable for use in the patient’s body. If you Google, Metabolic Hypothyroidism with my name, the article will provide you with much more information on this estrogenic thyroid binding.
- Estrogen in general, when exposed to normal tissue, will cause that tissue to grow.
- The elevated adrenal estrogen will also cause the immune cells to reduce their protection for the patient, causing chronic bacterial and viral infections.
- When the T-lymphocyte no longer protects the patient from viral diseases, this will be one of the major reasons why Feline Leukemia (FELV), Feline Immunodeficiency Virus (FIV), Feline Infectious Peritonitis (FIP) and HIV to AIDS will occur. All of the above viral diseases have elevated adrenal estrogen when measured.
- The elevated adrenal estrogen also causes the immune cells to lose recognition of self tissue and this is probably why autoimmunity may occur.
- The elevated adrenal estrogen will cause the B-Lymphocyte to reduce its production of immunoglobulin’s (antibodies). When this happens and the immunoglobulin in the intestines, referred to as immunoglobulin A (IgA) is deficient, malabsorption will occur with many different oral supplements, including steroids.
This is why it may be important to measure IgA, even before prescribing an oral supplement
In canine and feline patients, that level must be at 58mg/dL or higher
In humans that level is 68 mg/dL.
NOTE: An IgA deficiency may be the reason why a transdermal or an injection of a supplement like a steroid, may be necessary in order to enter the patient’s body before the supplement will work. Hopefully the day will come, when an IgA level will be measured with every standard blood test that is performed.
There are other estrogens that are produced in the body particularly from the ovaries, and that is why the 90,000 blood test results that I performed, came from female patients with no ovaries present and males with no testicles present and represent mainly inner layer adrenal cortex estrogen or total estrogen in these patients.
In certain tissues in the body, particularly the fatty tissue, there is an enzyme referred to as aromatase that can turn testosterone into a form of estrogen, referred to as estradiol.
If we think back and remember that excess estrogen can bind the thyroid hormones, this might be one reason why when men are given injections of testosterone, because of having low level testosterone. The aromatase in their fatty tissue creates estradiol, which will bind their T3 and T4 and cause them to gain weight, even to the point of being obese.
Stress and environmental exposure to phytoestrogens, xenoestrogens, chemicals, toxins, chemotherapy, radiation, medications anesthesia etc; all may alter the middle layer adrenal cortex and its production of normal amounts and types of cortisol.
I have noticed with many of the human patients that have an endocrine immune dysfunction and allergies, autoimmunity or cancer, all seem to have the following noticeable, physical characteristics;
- The lateral third of their eyebrows are either thin, or missing.
- They have dark circles under their eyes.
Any family members that seem to have these same physical characteristics might be wise to check their endocrine immune surveillance and if an imbalance is identified, the imbalance can be corrected before a disease develops in their future.
I would suggest the following tests that might be considered, in order to identify an endocrine immune imbalance in a patient:
NOTE; LabCorp has the total estrogen levels at different periods for women that are still menstruating.
I also have listed a much more comprehensive endocrine immune test in more detail in an article on this website titled, Important Facts Regarding Progesterone and Estrogen Including Some different Thoughts About, Total Estrogen
These are just some of my thoughts that hopefully may create some scientific interest and studies, and at the same time provide better health for you and your pet.
Dr. AL Plechner