Some Thoughts Regarding Early Aging

Posted on January 10th, 2017

Many of us worry about the life expectancy for ourselves and for our pets and is there anything we can do about it?

Obviously regular exercise, proper nutrition and proper amounts of sleep will help make a difference.

After many years of clinical practice, I have discovered that there is a way to maximize the time of life for both you and your pet.

What I have discovered is an endocrine mechanism that regulates the immune system.

What is this mechanism?

The mechanism begins with the normal production of cortisol from the middle layer adrenal cortex, which allows for the normal production of adrenal estrogen from the inner layer adrenal cortex.

Unfortunately, excess adrenal estrogen had not been considered since a human laboratory in the mid 1940’s decided that the human body only produced three kinds of estrogen which were estradiol, estrone and estriole. This seems to have guided the the direction of medical profession and has totally excluded the importance of excess adrenal estrogen.

As the cortisol works to help the immune system and fulfills its other functions in the body, the liver will breakdown the cortisol and the kidneys will excrete the end products.

When the amount of cortisol falls below a certain level, it will stimulate the hypothalamus and pituitary glands to release their hormones in this negative feedback mechanism, which will stimulate the middle, layer adrenal cortex to release more cortisol.

When this endocrine regulation is normal, the immune system remains normal also and will protect the patient whether humans or animal.

Unfortunately when the cortisol production is deficient or damaged, the release of the hormones from the hypothalamus and pituitary will continue.

Since the cortisol is deficient or damaged, the hypothalamus and pituitary continue their release of their hormones.

When this occurs, the inner layer adrenal cortex will respond in a direct feedback mechanism and produce excessive amounts of adrenal estrogen.

When this happens, the elevated amounts of adrenals estrogen cause the following in the body of the humans and the animal:

  • The elevated adrenal estrogen will cause inflammation of all the endothelial cells that line the arteries in the body.
  • The elevated adrenal estrogen will block the availability of the thyroid hormones for use in the body.
  • The elevated estrogen in general when exposed to normal tissue will cause the tissue to grow.
  • The elevated adrenal estrogen will deregulate the immune system in two major ways
  • The immune cells will no longer protect the patient from chronic bacterial and viral infections.
  • It will cause the immune cells to lose recognition of self tissue which may lead to autoimmune diseases and cancer.
  • The elevated adrenal estrogen will cause the B-Lymphocyte to reduce its immunoglobulin (antibody) production and when the mucous membrane antibody referred to as IgA is below a certain level, malabsorption will occur especially with many supplement and hormone replacements for cortisol.

NOTE: Fluorides will often replace iodine, which is necessary for the production of thyroid hormones. When this occurs the patient can become hypothyroid. Also since the fluoride compound that is created is foreign to the body, anti-antibodies may be made to this compound causing an autoimmune disease referred to as Hashimoto’s Syndrome.

Considering all this, I believe that the cortisol production from the middle layer adrenal cortex may be the Achilles’ tendon for the endocrine system.

When the normal levels of cortisol are changed or damaged, major chronic diseases may occur.

What are the various inputs that might adversely affect the cortisol production?

Stress happens to be one of the major offenders that can cause a cortisol deficiency.

When stress is present in the human or animal the production of adrenal uses cortisol as a catalyst causing what the medical profession calls Adrenal Fatigue.

There are many different environmental inputs that can also either cause the cortisol to be deficient or to be damaged.

Phytoestrogens, which are plant based estrogens that occur in foods may be a concern if you or your pet have a cortisol that has led to an endocrine immune imbalance.

I have included many of the foods that contain phytoestrogens and in an article you can Google with my name, the researchers at the University fo Toronto have compiled a list of phytoestrogen foods and the amounts of estrogen they contain. The article is titled New Information on Exact Quantities of Total Phytoestrogens.

I also have another article that might help on Google titled Natural Estrogens that Occur in Nutrients.

Fortunately, phytoestrogens are organic and more easily processed out of the body

Xenoestrogens are also of concern are chemical compounds that mimic estrogen but are not included in serum analysis for estrogen.

I also have an article on Google titled, Do Total Estrogen Blood Tests Include Xenoestrogens?

The most common xenoestrogens to try to avoid whenever possible are as follows:

1) House hold products

2) GMO foods

3) Personal hygiene products

4) Industrial products, including plastics

5) Building materials

6) Insecticides, etc.

Xenoestrogens are concentrated in fatty tissue and therefore it would be best to try to avoid ingesting any animals fats.

All of the above thoughts can lead to early aging even though many of them may be difficult to avoid.

What you can do, however, is make sure your endocrine immune surveillance remains normal for both you and your pet?

The next time you visit your health care professional or your veterinarian, you might ask them to add the following blood tests that will determine if your endocrine immune surveillance is normal, and if not, how to correct whatever imbalance is identified.

The following are the tests that need to be included:


Total or Adrenal estrogen






The above tests are very important also for prevention and also to stop early aging.

Unfortunately, adrenal estrogen or total estrogen has not yet been recognized by many in the medical and veterinary professions.

Once adrenal estrogen is routinely measured and determined that its levels are within the normal range, early aging will not occur.

LabCorp for humans and National Veterinary Diagnostic Service of animals can do this test including the other tests that are mentioned.

Yes, it is a very complex world that can lead to some unhappy health problems, unless you are aware of the some of the problems that lay in wait for you and your pet.

Hopefully my thoughts may be of value and will help you and your pet reduce early aging and the health hazards that accompany an endocrine immune imbalance.


Dr. Al Plechner