Did You Realize There is a Measurable Endocrine Immune Blood Test that Identifies the Cause of Allergies, AutoImmunity and Cancer in Humans and Animals?

Posted on March 22nd, 2017

During my past 50 years of dealing with allergies, autoimmunity and cancer, I have been able to identify the fact that they all seem to occur mainly due to the development of an endocrine immune imbalance.

Doing complete blood counts (CBC) and Blood Chemistries may help identify important changes that have occurred in the bodies of animals and humans, but the CBC and Blood Chemistry often do not indicate what the real cause of the disease may be.

What is often not realized is the fact that the endocrine system regulates the immune system and when an endocrine imbalance is present or develops, the immune system may no longer be properly regulated and perform in a manner that will protect the patient.

When this occurs, the immune system may no longer be able to protect the patient against chronic bacterial, viral, molds and fungi infections.

Also when this occurs, the production of one of the antibodies from the B-lymphocyte referred to as immunoglobulin A, is decreased below a certain level; loss of protection occurs of the gut, including significant malabsorption.

The reason that identifying a deficient IgA is important, is because many types of corrective medications cannot be absorbed correctly by the patient, and therefore may be worthless if taken orally.

In this instance, an injection of a long acting cortisol may be necessary for a short period of time.

What is this endocrine immune imbalance and why does it occur?

The actual damage that can occur to the endocrine immune system may begin due to the following types of adverse inputs:

. Altered genetics

. Medications

. Radiation including x-rays

. GMO = genetically modified foods

. Phytoestrogen = estrogen containing plants

. Xenoestrogens = estrogen mimicking chemicals

. Anesthesia

. Chemicals

. Food sensitivities

. Poor nutrition

. Surgery, etc.

What imbalances can these various inputs cause the endocrine immune system?

These various inputs can damage the production of normal amounts and types of active cortisol that are produced by the middle layer adrenal cortex, referred to as the Zona Fascicularis.

When this imbalance in cortisol occurs, the hypothalamus recognizes this imbalance and releases its hormone, referred to as Cortico-Releasing Factor (CRF). The CRF than causes the pituitary gland to release its Adreno-Corticotropic Hormone, referred to as ACTH.

The release of both of these hormones is designed to cause the release of more active and increased amounts of normal cortisol. This release is referred to as a negative feedback mechanism.

When the release of cortisol is deficient, bound or defective, the following may occur:

The Zona Reticularis will respond in a direct feedback mechanism and release elevated amounts of adrenal estrogen and adrenal androgen.

NOTE: This article will only deal with the elevated amounts of adrenal estrogen that are released.

Because the cortisol is deficient, bound or defective and cannot respond by releasing active, adequate amounts of cortisol, the CRF from the hypothalamus and the ACTH from the pituitary gland will stimulate the inner layer adrenal cortex, referred to as the Zona Reticularis, to release elevated amounts of adrenal estrogen.

The release of elevated amounts of adrenal estrogen will cause a number of different adverse conditions to occur in the body of the patient, whether human or animal.

The following is a list of those adverse conditions that elevate estrogen may cause:

. When elevated amounts of estrogen are exposed to normal tissue, the

    excess adrenal estrogen will cause that tissue to grow, not unlike the

    growth that occurs with cancer tissue.

. Elevated amounts of adrenal estrogen will cause inflammation of all

  the endothelial cells that line all the arteries in the patient’s body.

  The endothelial cell inflammation may indicate one reason why

  some forms of coronary occlusion occur including blood clots

. Elevated amounts of adrenal estrogen will bind the receptor sites for

  triiodothyronine (T3) and thyroxin (T4). This binding of the thyroid

  hormones can lead to a metabolic state of hypothyroidism, even with

  the production of normal amounts of T3 and T4.

  NOTE: I do have an article that deals with Metabolic Hypothyroidism

  on my website at http://drplechner.com/metabolic-hypothyroidism-revisited/.

. Elevated amounts of adrenal estrogen will cause the B-lymphocyte

  production of the mucous membrane immunoglobulin, referred to as

  IgA, to be reduced and deficient, and when the reduction of IgA is

  below 58mg/dL in canines and felines and below 68 mgs/dL in

  humans, malabsorption of oral replacement steroids and many

   other oral replacement substances may occur.

. Elevated amounts of adrenal estrogen will cause the B and T

   lymphocytes to stop their protective duties for the patient’s

  body and may allow for the development of chronic bacterial, viral,

  fungal and mold infections.

What endocrine immune blood tests are necessary to be performed in order to determine why an allergy, autoimmunity or cancer is present in a patient?

The following are a list of those endocrine immune tests that need to be measured in order to determine why the patient has developed one of these disorders:

. Cortisol

. Total or adrenal estrogen

. Triiodothyronine (T3)

. Thyroxin (T4)

. Immunoglobulin A

. Immunoglobulin M

. Immunoglobulin G

What are the normal expected values for these tests for canines, felines and humans?

For Canines and Felines = the following:

. Cortisol

   Males and females = 1.0 to 2.5 mcg/dL

. Total or Adrenal estrogen;

    Males = 24.5 to 25.0 pg/dl

    Females = 24.5 to 35 pg/dL

. Triiodothyronine (T3)

    Males and Females = 100-200 ng/dL

. Thyroxin (T4)

    Males and Females = 2.0 to 4.5 ng/dL

. Immunoglobulin A

    Males and Females = 70 to 170 mg/dL

. Immunoglobulin M

    Males and Females = 100 to 200 mg/dL

. Immunoglobulin G

    Males and females = 1000 to 2000 mg/dL

For Humans = the following:

. Cortisol

    Males and Females = 5.0 to 20 ug/dL

. Total or Adrenal estrogen

    Adult Males = 80 to 115 pg/dL

    Adult Females = 40 to 115 pg/dL

    Premenopausal males and females = less than 40 pg/dL

    Post menopausal women = 40 mgs/dL

. Triiodothyronine (T3)

    Adult Males and Females = 86 to 187 ng/dL

. Thyroxin (T4)

    Adult Males and Females = 4.5 to 12 ng/dL

. Immunoglobulin A

    Adult Males and Females = 70 to 312 mg/dL

. Immunoglobulin M

    Adult Males and Females = 56 to 352 mg/dl

. Immunoglobulin G

    Adult Males and Females = 639 to 1349 mg/dL

Hopefully the day may come when for the benefit for the patient an endocrine immune blood test will be included with a CBC and Blood Chemistry.

It is definitely important to measure a CBC and Blood Chemistry, but it might be even more important to also measure and correct the patient’s endocrine immune imbalance and competence.

These are just a few of my thoughts and I hope these thoughts might be of value in helping you and your pet attain a better degree of health.


Dr. AL Plechner