Many Different Human Diseases May Be Caused By Elevated Adrenal Estrogen

Posted on December 6th, 2016

In the mid 1940’s, a major human medical laboratory made the decision that there are only three types of estrogen that are produced in the human body. Those three types of estrogen are estradiol, estrone and estriole.

Today’s medical practices usually only measure these three types of estrogen, and are aware of the fact that a certain enzymes referred to as aromatase, that occurs in many tissues in the body, has the ability to transfer testosterone and female androgen into estradiol and adrostenedion into estrone.

My clinical studies have identified a fourth type of estrogen that is produced from the inner layer adrenal cortex, and when occurring in excess amounts, it will cause many different, significant types, of chronic medical diseases.

My studies over the past 50 years have measured adrenal estrogen in over 90,000 canines, felines, and equines.

I have also been privileged to work with a number of MD’s and have also have had them measure adrenal estrogen in 2,000 human patients. If you Google "The Results of an International Convention for Integrative MD Oncologists, Regarding Dr. Plechner’s Findings for Many Different Chronic Human Diseases" with my name, it will discuss the findings of one of the MD’s I have worked with recently.

I was very privileged to work with Dr. Richard Pooley, who presented two cases of patients with cancer and one case of a a patient with an autoimmune thyroid disease at this convention, and how these patients were treated successfully by reducing the their adrenal estrogen and changing the effects that their elevated estrogen was causing on other systems in the body.

Also, what my clinical studies have indicated over the past 50 years of practice is that an endocrine mechanism exists, that regulates the immune system.

It appears that the immune system does not operate on its own, but rather is regulated by certain hormones, one of which is adrenal estrogen.

What is this mechanism, and how does this mechanism work?

This mechanism begins with the negative feedback mechanism between the cortisol produced in the middle layer adrenal cortex, hypothalamus and the pituitary glands.

Under normal health conditions, the middle layer adrenal cortex releases its hormone called cortisol. The cortisol fulfills its function in the body, including its regulation of the immune system, and is slowly metabolized and as its levels decrease, the hypothalamus releases its hormone Cortical Releasing Factor (CRF), which causes the pituitary gland in turn, to release its hormone Adrenal Corticotrophic Hormone (ACTH).

The ACTH causes the middle layer adrenal cortex to release more cortisol and the immune regulation remains normal and functioning.

However, if the middle layer adrenal cortex is producing deficient amounts of cortisol or a defective type of cortisol, the hypothalamic-pituitary axis will continue producing their hormones, CRF and ACTH.

When this occurs, the inner layer adrenal cortex will respond by producing excessive amounts of adrenal estrogen.

What effects does this excessive amount of estrogen have on other parts of the patient’s body, including their immune system?

The following list is what problems the excessive adrenal estrogen will cause:

  • The elevated adrenal estrogen will cause an inflammation of the endothelial cells that line all the arteries in the patient’s body;
  • The elevated adrenal estrogen will invalidate the use of the two thyroid hormones triiodothyronine (T3) and thyroxin (T4);
  • The elevated adrenal estrogen will deregulate the immune cells which are the B and T lymphocytes.

When this occurs, both the B and T lymphocytes will not perform their protective duties for the patient.

They also will lose recognition of self tissue and this may allow for the development of autoimmune diseases.

  • The elevated adrenal estrogen will cause the B-lymphocyte to reduce its production of immunoglobulin’s (antibodies) and when the mucous membrane immunoglobulin called IgA is below a certain level, many oral supplements and medications including steroids, will not be  able to be absorbed.
  • When estrogen is applied to normal tissue in a Petri dish, the normal tissue will begin to grow.

If you consider the damage that an elevated amount of adrenal estrogen can do to a patient, I wonder why adrenal estrogen is not measured routinely.

The following are merely my thoughts regarding various chronic diseases that that may be occurring in human patients, based upon what I have seen with my own animal patients.


Let’s think about elevated adrenal estrogen causing inflammation of the endothelial cells that line all the arteries in the patient’s body.  I would think it might be worthwhile measuring adrenal estrogen with a disease like Alzheimer’s Syndrome, when an inflammation of the cerebral arteries of the patient, is thought to be the cause.

I wonder about the effects of elevated adrenal estrogen on patients with coronary occlusion, which includes arteriosclerosis and atherosclerosis?

Since elevated adrenal estrogen invalidates the use of the thyroid hormones, it is easy to see why an elevated adrenal estrogen can cause a patient with normal thyroid hormone levels to become obese and not to be able to lose weight. For more information on this subject please Google "Metabolic Hypothyroidism" with my name.

When the elevated adrenal estrogen causes the immune system to become deregulated and no longer protect the patient, chronic bacterial and chronic viral diseases may occur.

When the B-lymphocyte is no longer functioning to protect the patient, I would expect that patient to suffer from multiple chronic bacterial infections; involving various organs and parts of the their body.

When the T-lymphocyte is no longer functioning to protect the patient, I would expect the patient to suffer from multiple chronic viral infections. Chronic colds and flu might be common, but what about a chronic, viral hepatitis B and C?

HIV developing into AIDS may also be involved. I have found this to be true with viral diseases in felines that have Feline Leukemia, Feline AIDS and Feline infectious Peritonitis.

A number of years ago, I was given the opportunity to have an MD in Chicago test six of his patients that had AIDS.

They all had this mechanism imbalance that caused the production of elevated amounts of adrenal estrogen.

My understanding at the time, all patients became much better and were able to carry on their normal lives.

Considering excess adrenal estrogen causing tissue growth; all the patients I have checked, which included canines, felines and equines that had cancer, all had elevated amounts of adrenal estrogen.

The MD’s that have worked with me over the years all had cancer patients with elevated amounts of adrenal estrogen.

Many times their patients had normal or deficient amounts of estradiol.

This can also lead to a very serious medical situation for any postmenopausal woman when prescribed an estrogen supplement without first measuring her adrenal estrogen, because if her adrenal estrogen is in excess, the introduction of an estrogen supplement might cause her to develop allergies, autoimmunity or even cancer.

I would think it might be advisable for any cancer patient to at least have their adrenal estrogen measured, because reducing the adrenal estrogen might help stop continued tumor growth.

My studies have also indicated that when the B-lymphocyte production of the mucous membrane antibody IgA is below a certain level, malabsorption of oral supplements and medications including steroids may occur.

In canines and felines, the IgA level must be at 58 mg/dL or higher for proper absorption to occur.

In humans, that level for proper absorption must be at 68 mg/dL or higher.

This article is definitely not to say not follow the directions given by your healthcare care professional. It is only to say if any of my thoughts seem reasonable to you and you are suffering from any of these above diseases, you may want to have the following tests added to what your health care professional is already measuring:


Total estrogen












and IgG.

From a preventative standpoint either for health reasons or for a concern about inheriting a predisposed family disease, this following shorter test version may be enough to indicate to you and your health care professional if you have an endocrine immune imbalance that needs to be corrected before a disease process begins.

This shorter test version is as follows:


Total estrogen







and IgG.

A last minute thought also may indicate that this regulatory endocrine immune mechanism has a lot to do with anti-aging.

Please know that these are only my thoughts, but my thoughts are based upon 50 years of clinical testing and experience.

Hopefully some of my thoughts will be of value to you and your health care professional..


Dr. Al Plechner