A LITTLE UNDERSTOOD MIDDLE LAYER ADRENAL CORTEX THAT IS THE CAUSE OF MANY ALLERGIES, AUTOIMMUNITIES AND CANCER.
There are three layers anatomically that make up the adrenal cortex.
All three layers have different functions, and yet the middle layer adrenal cortex, referred to as the Zona Fasciculata, is the least understood adrenal layer.
The first adrenal cortex layer, known as the Zona Glomerulosa, produces its hormone referred to as Aldosterone.
The function of Aldosterone is to act mainly on the functional unit of the kidneys. It aids in the loss of sodium, secretion of potassium, water retention, and to help stabilize blood pressure.
This syndrome is referred to as Addison’s Syndrome.
When Addison’s Syndrome is diagnosed, but the clinical signs and symptoms do not represent what is occurring in the patient, the syndrome is then referred to as Atypical Addison’s Syndrome.
This Syndrome is due to a lack of understanding that these clinical signs and symptoms that are coming from a deficiency or an imbalance in the middle layer adrenal cortex and a deficiency or imbalance in the hormone produced in the middle layer adrenal cortex, referred to as Cortisol.
The second adrenal cortex layer, known as the Zona Fasciculata, produces its hormone referred to as Cortisol.
When there is an excess production of active Cortisol, the syndrome is referred to as Cushing’s Syndrome.
When Cushing’s Syndrome is diagnosed, but the clinical signs and symptoms do not represent what is occurring in the patient, the syndrome is then referred to as Atypical Cushing’s Syndrome.
What is not yet realized yet, is that the production of Cortisol can be defective and non-functional.
To measure Cortisol by itself, is of very little value, and must be measured with adrenal estrogen, which is produced in the third layer of the adrenal cortex, referred to as the Zona Reticularis.
If the production of Cortisol is elevated above normal and the adrenal estrogen which is measured as Total estrogen is also elevated, it indicates that the hypothalamic-pituitary axis, does not recognize the non-functional elevated cortisol, and they will keep producing their hormones, which in turn, will stimulate the release of excess, adrenal estrogen.
The third layer of the adrenal cortex is known as the Zona Reticularis and produces its hormones, referred to as adrenal Estrogen and Androgen.
When the middle layer of the adrenal cortex produces a deficient, or non-functional cortisol, even if its levels are elevated, the Cortisol deficiency or imbalance will NOT fund the negative feedback mechanism to the hypothalamic pituitary axis, which will lead to the production of elevated Estrogen and Androgen.
NOTE: This paper will only deal with elevated adrenal Estrogen, which can be measured as Total Estrogen.
The middle layer adrenal cortex production of normal Cortisol is poorly misunderstood.
Its normal production of cortisol can be damaged due to many different in puts.
I personally believe that the middle layer adrenal cortex, and its production of cortisol, is the endocrines answer to the Achilles’ tendon of the body.
The following are just a few of the damaging inputs that can alter the normal production of Cortisol:
. Estrogen mimicking substances.
When any of these damaging in puts occur, the alteration in the production of normal Cortisol, will not be recognized by the hypothalamic- pituitary axis, and their CRF and ACTH from these endocrine glands, will continue their hormone, production, which causes the third layer of the adrenal cortex, to produce excess amounts of adrenal estrogen.
When this excess adrenal Estrogen occurs, the following changes will happen in the patient;
- The availability for the use of thyroid hormone is invalidated.
- The B and T lymphocytes are deregulated.
- When this occurs:
The B-Lymphocyte will no longer protect the patient against bacterial infections and will not produce protective antibodies when exposed to various kinds of bacteria and vaccinations.
- The T-Lymphocyte will not protect the patient against viruses and fungi including Candida.
- When the B-Lymphocyte production of antibodies (immunoglobulins) is decreased, especially in the intestines, absorption of many different medications, including Cortisol replacements, will not be absorbed orally.
- My clinical blood test analysis, done in canines and felines, including humans, suggest that the intestinal antibody, immunoglobulin A (IgA), needs to be at the following level for absorption to occur:
. Canines and Felines = 58 mg/dL
. Humans = 68 mg/dL
Note: An IgA level should be included with all standard blood tests in order to insure the fact, that the patient can absorb the oral medication that is being sent home by the health care professional.
- The hormonal deregulation of the B and t-Lymphocytes allow for them to lose recognition of self-tissue and this is when autoimmunity and cancer may occur
- This Syndrome that I have discovered, I refer to as Atypical Cortisol Estrogen Imbalance Syndrome (ACEIS).
This Syndrome identifies the CAUSE of many allergies, autoimmunity and cancer.
Therefore, treating the CAUSE of disease, as opposed to merely treating the effects of disease, lies the truth.
Hopefully, this article will help you understand the importance of the middle layer adrenal cortex and the importance of having the production of normal Cortisol in order to maintain a healthy, happy, long life.
Dr. AL Plechner