By Alfred J. Plechner, D.V.M.

Have you ever wondered why the actual cause of cancer might be an endocrine-immune imbalance in you or your pet? Most of the treatment for cancer deals with only treating the effects of the uncontrolled tissue growth, whether through surgery, radiation, chemo therapy, diet, supplementation and low stress practice, and not the cause. Obviously treating the effects are of major importance, but without actually treating the cause, the unidentified endocrine-immune imbalance will either have the cancer continue to grow, or cause the cancer to return.

What then is the cause of this uncontrolled tissue growth called cancer? It occurs because of a endocrine-immune imbalance that leads to a deregulated immune system. This endocrine-immune imbalance begins with a defective or deficient cortisol which is produced in the middle layer adrenal cortex.

Did you realize that the normal daily cortisol production for you and your pet is thought to be 30 to 35 units daily? When this occurs, there is a feedback deficit to the pituitary which in turn is asking for more active cortisol. When the middle layer adrenal cortex cannot produce any more viable cortisol, the inner layer adrenal cortex responds by producing excess adrenal estrogen.

What does this excess adrenal estrogen actually do that is caused by this endocrine-immune imbalance? It causes the production of a type of thyroid hormone referred to as reverse T3 that blocks the receptor sites for active thyroid hormone availability. This in turn, this endocrine-immune imbalance, causes the metabolism of many detoxifying organs to slow down and allow this excess adrenal estrogen to remain and actually increase in its amounts and its damage to the body.

At the same time, the estrogen deregulates the immune system which no longer protects the body with its functions, but also allows these immune cells to lose recognition of self tissue and begin to make antibodies against red blood cells, white blood cells, platelets, muscle and nerve tissue connective tissue and many other parts of the body.

Yes, cancer occurs with this endocrine-immune imbalance but so does auto-immunity. The literature indicates when normal tissue is exposed to excess estrogen, uncontrolled tissue growth occurs. It is thought that the immune system is deficient, but this is not the case. The immune cells are deregulated and using immune stimulators may only make this deregulation worse.

The only deficiency that occurs with this endocrine-immune imbalance is with the production of antibodies. This antibody deficiency allows for foreign invaders to overwhelm the patient due to low immunity. This endocrine-immune deregulation also disallows the production of protective antibodies to be created through vaccination but due to the estrogen blocking the availability of active thyroid, may also lead to a definite overdose, and severe side effects upon administering the vaccine. Further protection for this endocrine-immune imbalance comes with this lack of antibody production. If laboratory testing is proper, all main antibodies will be deficient in animals and only certain antibodies will become deficient with humans.

What then may happen? If you first look at the most primitive antibody in the body, it is referred to as immunoglobulin M (IGM). This is the first line, primitive antibody that is the road block antibody for foreign invaders whether virus or bacteria and allows time for the well defined antibody to be specifically produced. This is the antibody found in sharks. The immunoglobulin G (IGG) is the antibody that is produced against a specific organism or vaccine.

Immunoglobulin A (IGA) is the antibody found in all the mucous membranes of the body and is there for the protection of all the organs etc in the body, which is usually not measured with a standard health blood check. When this level is decreased, mal absorption occurs with oral supplementation and treatment. The supplement or the medication cannot reach the blood stream by way of the mouth.

A classic example of an endocrine-immune imbalance that causes a low gut IGA and malabsorption is with a patient that is hospitalized on intravenous or intramuscular injections of a specific antibody to help this disease that has been caused by this endocrine-immune imbalance and low IGA. When the patient is released from the hospital, and the same antibiotic sent home for oral use, the patient not being able to absorb through this reduced IGA, fails at home.

Often a new medication will be prescribed when it is not realized that this endocrine-immune imbalanced has caused a low IGA. What is the point in trying a new medication that will also not be absorbed through the gut? Hopefully the day will come when an endocrine-immune blood panel will be standard on all blood tests in order to make sure what is prescribed by the health care professional will be available orally for both you and your pet if the IGA level is low.

This is why many oral medications, vitamins, supplements and nutrients, used to fight cancer and auto-immunity, do not work! The next stumbling block is handling the blood samples correctly by your healthcare professional, and also the laboratory doing the blood test.

For further information, please take a look at the other articles on this web site.

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