Elevated Adrenal Estrogen, the Cause of Many Diseases in Humans and Animals

Posted on January 8th, 2016

During my 50 years of clinical, veterinary practice, I have been given the opportunity to complete over 90,000 endocrine immune tests in animals and more than 2,000 endocrine immune blood tests in humans

I have found that most chronic, catastrophic diseases in animals and humans, originate from an imbalanced adrenal cortisol that leads to an elevated adrenal estrogen, which deregulates the immune system.

Immune deficiency does not seem to be the issue, but rather immune deregulation is the issue.

When the T-lymphocyte does not protect the patient against viruses and fungal infections, and the B-lymphocyte does not protect the patient against bacterial infections and the protection from foreign invaders, including vaccinations this deregulation unfortunately allows the T and B lymphocytes to lose recognition of self-tissue and this is why autoimmunity and cancer supposedly occur.

I have discovered that there are two main sources of estrogen that are produced in animals and in humans.

The one recognized source of estrogen, comes from the ovaries.

The other unrecognized source of estrogen, comes from the inner layer adrenal cortex.

If either you, your family or family pet are suffering from allergies, autoimmunity or cancer, you might consider asking your health care professional to include total estrogen with the tests they are already prescribing.

Treating the effects of disease is important, but identifying the cause of the disease and doing the necessary treatment to correct the cause of the disease, is even more important.

Each patient that I was given the opportunity to diagnose, whether animal or human, all had elevated adrenal estrogen that was not included, in most standard blood tests done for animals and for humans.

Because we live in such a changing and toxic environment, it becomes even more important to recognize, an endocrine immune imbalance in animals or humans, in order for all of us to survive.

Of the 2,000 human patients that have allergies, autoimmunity and cancer and were tested for this imbalance, all had elevated adrenal estrogen.

What was the reason why total (adrenal) estrogen has not been included in standard blood tests?

I think the main reason for this occurring, is due to the fact that in the late 1940’s the medical laboratories made the decision that the three main sources for the production of estrogen in the body, came from the ovaries, and were estradiol, estrone and estriole.

These were the three main types of estrogen that the medical profession uses to decide if there might be a problem with their patient, and the production of excess, ovarian estrogen.

Adrenal androgen (testosterone) was thought to be the only sex hormone that was produced by the inner layer adrenal cortex, referred to as the Zona Reticularis.

It is thought that any estrogen that might be produced by the inner layer adrenal cortex, will be one or all of the same types of estrogens that are produced by the ovaries.

All my clinical studies in animals and in humans, indicate that there are a different types of estrogen that was being produced by the adrenal cortex.

NOTE: The medical profession has identified a small amount of estrogen that is produced by the skin, fat and brain tissue, of patient.

NOTE: If you are interested in testing for for adrenal estrogen, the laboratories will have it listed as total estrogen and not adrenal estrogen.

All my tests were either done on male animals or female animals, with no ovaries.

All their adrenal estrogen was elevated, because their cortisol levels were not working correctly, whether deficient, or normal and elevated and defective. This is another fact you need to be aware of.

If a laboratory result is in a normal empirical, hormone range, it does not indicate whether that hormone can be used by the body or not.

24 hour urine samples and multiple salivary tests are important to identify a deficiency in a hormone.

However, even if that hormone is free and within the normal range, it DOES NOT indicate whether the body can utilize that hormone, or not.

A normal laboratory, hormone level, is only empirical and not comparative, and will not indicate whether the hormone can be utilized by the body, and used by the body, and this is why, it is so important to check the end products in the body, that the hormone regulates.

I have found this to be true with an endocrine immune imbalance in cortisol with both animals and with humans.

A prime example of this, is with identifying an empirical amount of cortisol.

When the cortisol is measured included with an endocrine immune imbalance, it may not fund the negative feedback mechanism to the hypothalamic=pituitary axis, which causes the production of large amounts, of adrenal estrogen, when there is a cortisol imbalance.

This is why it is so important while measuring cortisol, that adrenal estrogen should also be measured, in order to indicate, whether the cortisol is active or inactive, and can be used by the body.

It is very important to also recognize the fact that the medicine profession does worry about the effects that elevated estrogen causes in the body, for cancer and uncontrolled tissue growth, but so far, adrenal estrogen has not been included.

I have proven in animals that allergies, autoimmunity and cancer, all come from an endocrine immune imbalance which causes the production of excessive amounts of adrenal estrogen.

The humans that I have suggested that their MD’s test for this imbalance, all had endocrine immune imbalances including, elevated adrenal estrogen

The following are a list of the diseases that I found in 2,000 humans patients over the years that had all suffered from an endocrine immune imbalance that created an elevated adrenal estrogen.

  • MS
  • AIDS
  • IBS whether caused by ulcerative colitis, food allergies, acid reflux or Chrone’s disease
  • ALS
  • Insect sensitivities
  • Vaccine reactions
  • Post Traumatic, Stress Syndrome
  • PMS
  • Chronic Lyme’s disease
  • Chronic Candida and other non-responsive fungal and yeast infections
  • Epstein Barr virus
  • Many other chronic diseases
  • All different kinds of cancer that occur, which are due to uncontrolled tissue growth, that comes from an elevated estrogen that is not being measured.

The six male prostate cancer patients that I was allowed to make suggestions for, all had normal estradiol, but their adrenal estrogen, which should have been 80 to 115 pg/ml, was more than 500mgs/ml.

I guess my question to you is, if you or your pet have an endocrine immune imbalance, that is a causing chronic disease, there may be a better way to correct this imbalance that so far, seems to not have been discovered.

I think if you begin to be concerned about elevated adrenal estrogen, causing chronic endocrine immune imbalances, you may want to have your health care professional, determine if you or your pet, have this imbalance.

In discovering this endocrine immune imbalance that leads to an elevated adrenal estrogen, makes me wonder how many other chronic diseases are caused by elevated adrenal estrogen that is caused by a deficient or a defective cortisol?

There are so many different chronic diseases that may come from an imbalanced, endocrine immune system that might be helped, by only identifying an elevated estrogen and so far, there seems to be no interest.

The time has come to check this imbalance especially when a chronic disease has been identified in you, a member of your family, or your family pet.

It would be very simple to only have your health care professional, include a total estrogen, with the other prescribed, blood tests.

I have been very concerned, if elevated adrenal estrogen might be the cause of some of the following diseases, but so far there seems to be no interest to find this out!
  • Autism
  • Alzheimer’s syndrome
  • Dementia
  • Parking’s syndrome
  • Hashimoto’s syndrome
  • Muscular Dystrophy
  • All kinds of cancer that have estrogen receptors, that are promoted by elevated amounts of estrogen like breast, prostate and pancreatic cancers.

Why not also measure adrenal estrogen and identify the fact that adrenal estrogen may be the cause of these various chronic diseases, or not.

I have found a better way for you and your family and pets to live, however the total estrogen test, in comparison to testing for the three ovarian estrogens, may help you, your family and your pet, survive our genetically altered, environment.

If you decide to test for adrenal estrogen and it is elevated, in order to help correct this imbalance, the following tests need to be performed.


  • Males
    • Cortisol
    • Total estrogen
    • Estradiol
    • Total T3
    • Total T4
    • TSH
    • TBG
    • Reverse T3
    • Iodine
    • IgA
    • IgM
    • IgG
  • Females
    • Cortisol
    • Total estrogen
    • Estradiol
    • Estriole
    • Estrone
    • Total T3
    • Total T4
    • TSH
    • TBG
    • Iodine
    • IgA
    • IgM
    • IgG
    • Note: For the women that are still menstruating, it would be best to do this test at the end of the first week of their ovarian cycle.


  • Males and Females
    • Cortisol
    • Total estrogen
    • Total T3
    • Total T4
    • IgA
    • IgM
    • IgG

NOTE: Any human laboratory can perform these tests, however there is only one veterinary laboratory that can perform these various tests at this time. They can be contacted here, National Veterinary Diagnostic Services.

I personally believe that the reason that allergies, autoimmunity and cancer are occurring so frequently in people and animals, is because of all the environmental toxins and stress that adversely affects their Achilles’s tendon of the body that I now think, is the middle layer adrenal cortex and its production of normal, regulatory cortisol.

Soon, I will post an article on why I believe the middle layer adrenal cortex, is the Achilles’ tendon of our environmental world.

This article will help indicate how the different environmental exposures, stress and genetics, are causing our MEDICAL AND ENVIRONMENTAL ICE AGE.

These are merely my own thoughts, which I hope will help you, your family and your family pet, survive our coming years of a toxic environment.


Dr. AL Plechner