Elevated Adrenal Estrogen is Merely an Effect Which Causes Many Different Chronic Diseases in Humans and Animals

Posted on March 6th, 2017

Where does the adrenal estrogen come from and why can it be elevated?

Adrenal estrogen originates from the inner layer adrenal cortex called the Zona Reticularis.

When quantities of adrenal estrogen become elevated, it is because of the middle layer adrenal cortex referred to as the Zona Fasciculata,  producing either deficient of defective amounts of cortisol.

When the middle layer adrenal cortex produces a deficient or defective cortisol, it damages the negative feedback mechanism to the hypothalamic-pituitary axis.

If the adrenal cortisol amounts are normal after it provides its functions in the body, it is broken down in the liver an excreted by the kidneys. The lower level of normal cortisol stimulates the hypothalamus to release its hormone CRF, which in turn stimulates the pituitary gland to release its hormone, which is ACTH.

When this bilateral hormone release is complete, they will stimulate the middle layer adrenal cortex to release more amounts of normal cortisol.

This relationship between the middle layer adrenal cortex and the hypothalamus and pituitary glands is referred to as a negative feedback mechanism.

However when the adrenal cortisol is deficient or defective, it cannot fund its portion of the negative feedback mechanism.

Therefore since normal cortisol cannot be released, the hypothalamus and pituitary glands continue to release their CRF and ACTH hormones.

This bilateral release creates a direct feedback mechanism to the inner layer adrenal cortex.

When this occurs, the bilateral hormone release causes the inner layer adrenal cortex to produce elevated amounts of adrenal estrogen and androgen.

The effects of this direct feedback mechanism creates elevated amounts of adrenal estrogen, which causes multiple diseases, based upon the damage that can be done with the elevated amounts of estrogen in general.

The multiple effects that total (adrenal)estrogen can cause are the following:

. When estrogen is exposed to normal tissue in a Petri dish, it cause that normal tissue to grow.

. Elevated estrogen causes inflammation of all the endothelial cells that

   line the arteries in the body.

. Elevated estrogen binds the receptor sites of the thyroid hormones.

. Elevated estrogen will suppress the immune system, disallowing the

   immune system from providing their protection that the body


. Elevated estrogen causes the immune system to lose recognition of self

  tissue and cause autoimmunity.

. Elevated estrogen will reduce the production of immunoglobulins

  produced by the B lymphocyte and when that mucous membrane

immunoglobulin in the intestines is below a certain level,

malabsorption occurs, which can also lead to many other significant


Unfortunately adrenal estrogen has not been recognized by the medical profession and included with all the other recognized sources of estrogens.

Adrenal estrogen seems not to exist, based upon the fact that in the mid 1940’s, a prominent human laboratory made the decision for the medical professions that the only estrogen being produced by the body are estradiol, estrone and estriole. Adrenal cortex estrogen was never mentioned and even today, adrenal estrogen is not thought to be significant.

Including humans and animals with allergies, autoimmune diseases and cancer, it is important to have your MD or DVM include a total estrogen test with the normal blood tests they also do for these various diseases.

Hopefully the day will come when the medical professions will realize that elevated amounts of adrenal estrogen will cause many different chronic, catastrophic diseases.

The following is a list of the laboratories that are measuring total (adrenal) estrogen:

Human laboratories = LabCorp and Quest

NOTE; LabCorp normal ranges for values for total estrogen are as follows:

Prepubertal = less than 40pg/dL

Post pubertal = less than 40pg/dl

Adult males = 80 to 115 pg/dL

Postmenopausal women = 40pg/dL

Menstruating women

  Day 1 to 10 = 61 to 394pg/dL

  Day 11 to 20 = 122 to 437pg/dL

  Day 221 to 31 = 151 to 358pg/dL

Veterinary laboratories = National Veterinary Diagnostic Services.

NVDS levels of total (adrenal estrogen are as follows:

Male and female canines = 24.5 to 25pg/dL

Male and female felines = 24.5 to 25pg/dL

If you or your pet are plagued with any of the above diseases, please ask your health care professional to include a total (adrenal) estrogen test in the blood tests that they are already planning to do.

These are just some of my thoughts that hopefully will help both you and your pet heal from allergies, autoimmune disease and cancer


Dr. AL Plechner