Is Elevated Adrenal Estrogen the Major Cause of Severe Allergies, Autoimmunity and Cancer in Animals and in Humans?

Posted on January 27th, 2017

Over the last 50 years of clinical veterinary practice, I have noted that in 90,000 canines and felines with allergies, autoimmunity and cancer, which have had their ovaries and their testicles removed, all had elevated adrenal estrogen.

Most medical laboratories measure adrenal estrogen under the label of total estrogen or completely missed, which is now beginning to change.

Their excess adrenal estrogen was caused due to a measurable production of a deficient or defective cortisol and once the cortisol imbalance was corrected, the excessive adrenal estrogen was reduced to normal levels, and their primary endocrine immune imbalances, disappeared.

I found this also to be true in a large number of human patients in which I was asked to help by their health care professionals.

You can receive more information about humans and the effects of elevated adrenal estrogen by going to Google with my name and an article titled “The Results of an International Convention for Integrative MD’s Regarding Dr. Plechner’s Findings, for Chronic, Human Diseases.”

Apparently the medical profession seems not to be aware of the importance of elevated adrenal estrogen just yet and the catastrophic diseases that it can cause.

I have wondered over the years, why the importance of adrenal estrogen has not been recognized for its importance by now.

In searching the medical literature, I came across an interesting history regarding estrogen.

In the mid 1940’s, an important human medical laboratory made the decision for the medical profession, that the following estrogens were the only estrogens that the body produced.

The estrogens that they named were estradiol, estrone and estriole only, and adrenal estrogen was never mentioned or examined.

Adrenal Exhaustion is a recognized medical disease, which occurs when the middle layer adrenal cortisol becomes deficient. All the effects, clinical symptoms and clinical signs are assigned to the cortisol deficiency only, and usually nothing else.

What is really happening may not be fully understood.

The cortisol works with the hypothalamic-pituitary axis in a negative feedback mechanism.

When the cortisol production from the middle layer adrenal cortex becomes exhausted and deficient, because of stress or many other different environmental inputs, the hypothalamus and pituitary glands release their hormones CRF and ACTH, causing the middle adrenal cortex to release more cortisol.

Once the cortisol release is complete and normal, the hypothalamus and pituitary glands stop the release of their hormones CRF and ACTH, completing the negative feedback mechanism.

When the middle layer is exhausted and cannot release proper amounts of cortisol, the inner layer adrenal cortex responds in a direct feedback mechanism, and releases excessive amounts of adrenal estrogen and androgen.

NOTE: This article will only deal with the release of excessive amounts of adrenal estrogen and not the release of excessive amounts of adrenal androgen, which can also lead to other major endocrine immune imbalances.

What does the excess amounts of adrenal estrogen cause?

It may cause the following changes in the body of the patients:

  • It causes inflammation of the endothelial cells that line all the arteries in the body. This effect may relate to the cerebral inflammation that an Alzheimer’s patient may suffer and possibly a type of heart disease that occurs due to coronary occlusion from arteriosclerosis and arthrosclerosis.
  • Estrogen, when exposed to normal tissue will cause the tissue to grow. This effect may be involved with causing cancer.
  • It will make the thyroid hormones unavailable for use in the patient’s body. For further information on this subject, please Google Metabolic Hypothyroidism with my name.
  • It will deregulate the immune system and the following can happen;
  • It will cause the B and T lymphocytes not to protect the patient’s body against bacterial and viral infections. When the T-lymphocyte is deregulated and will not protect the patient against viruses. This is the reason feline patients break with Feline Leukemia, Feline Immunodeficiency Virus, Feline Infectious Peritonitis.

               Human patients can be exposed to the HIV virus and with a T lymphocyte deregulation the HIV virus can cause AIDS. It also makes you wonder if Chronic Hepatic,

               Viral, Diseases are also related to this T-Lymphocyte deregulation, due to the production of excessive amounts of adrenal estrogen.

NOTE: 30 years ago, I was asked by an MD in Chicago, to get involved with 6 of his AIDS patients. What we found with all six patients with AIDS, was that they all had elevated amounts of adrenal estrogen. I never received any follow up after these initial findings.

  • It will cause the immune cells to lose recognition of self tissue and may cause autoimmunity and possibly be involved with cancer.

Hopefully the above discussion will indicate many of the disease possibilities that may happen when adrenal estrogen is elevated.

Many estrogen dominant diseases may have normal or deficient amounts of estradiol, estrone and estriole, which would make you wonder if elevated adrenal estrogen had been measured, might it have been elevated?

Other professionals have also recognized the importance of elevated adrenal estrogen.

Their thoughts are as follows:

“Adrenal Estrogens are produced in levels that are constant, regardless of age and gender. It is our belief that they are the source of many different conditions that are seen throughout the medical community which have been successfully treated using Dr. Plechner’s methods and protocols. When a patient’s levels are normalized, the presenting condition is usually minimalized or even eliminated” – Jason MacDonald MLT, National Veterinary Diagnostic Services, LLC

Even though the medical profession and most of the veterinary profession still do not recognize the importance of elevated adrenal estrogen yet, I would hope any human or pet owner that has found themselves, dealing with allergies, autoimmunity or cancer with themselves or with their pet, it might be of value to check Total (adrenal) estrogen.

LabCorp can measure total estrogen for humans as can other human laboratories, but the LabCorp normal ranges are more accurate.

National Veterinary Diagnostic Laboratories is the only veterinary laboratory that can do adrenal estrogen.

Hopefully these thoughts and information will help both you and your pet lead a happier, healthier life for the present and for the future..


Dr. Al Plechner

Below is a letter from National Veterinary Diagnostic Services regarding testing performed at the lab:

Endocrine/Immune Testing performed by National Veterinary Diagnostic Services, LLC

In the past 25 years we have had the privilege of working closely with Dr. Al Plechner and continuing his treatment and research in the veterinary community by utilizing testing that measures the levels of Adrenal Estrogen (formerly testing for Total Estrogen), Resting Cortisol, Total T3, Total T4, IgA, IgG and IgM.

When I took over the testing for Endocrine/Immune disorders from the lab which had modified the Total Estrogen testing protocol, the Total Estrogen kit was a commercially manufactured kit for humans and was successfully modified for use in animals. All of the other tests used kits that were commercially available as is.

Several years ago, the company that was manufacturing the kits for Total Estrogen decided that they were going to discontinue making the kits. This left us with the difficult task of creating our own test kits to perform the necessary analysis. We worked diligently to create our own protocol, and after much trial and error, we finally had one that was accurate and dependable.

Over the years we have further refined and developed the testing to increase the accuracy and diagnostic value of the test. In doing so, we have been able to eliminate the three primary Estrogens and pinpoint the long overlooked Adrenal Estrogen. This is important because Adrenal Estrogens are produced in levels that are constant, regardless of age and gender. We believe that Adrenal Estrogens are the source of many different conditions that are seen throughout the veterinary community which have been successfully treated using Dr. Plechner’s protocols.

Next we worked on the Immunoglobulins (IgA, IgG and IgM). The company that was also manufacturing these test kits decided to discontinue making them available to other labs and run the testing exclusively in-house. This again left us in a position where we could develop our own protocols and methods in order to continue to offer this valuable testing. After developing a viable alternative to the testing, we ran hundreds of parallel samples using the old method and the new, and we again have been able to accurately reproduce the same results.

The Cortisol, Total T3 and Total T4 remain as they have in the past, using commercially available materials and kits.

As we continue to look to the future, we strive to be a leader in the field and are constantly looking for ways to further advance the quality and care within the veterinary community.

Jason MacDonald, MLT