There is a world of hurt for both humans and for pets that may suffer from both an upset gut and a bladder disease.
Wikipedia reports that Irritable Bowel Syndrome (IBS) in humans and animals is characterized by abdominal pain and discomfort, bloating, and an alteration in bowel movements, from diarrhea to constipation. It is thought that this discomfort comes from bowel inflammation.
Wikipedia also reports that inflammatory bowel disease can also cause a bladder inflammation referred to as an Interstitial Cystitis or IC/BPS.
IC/BPS is a chronic inflammatory condition of the submucosal and muscular layers of the bladder. The clinical symptoms and signs are frequent, painful urination, frequent urination and necessary urination many times day and night.
Most humans that have this syndrome often have to urinate frequently all night long.
There are scientific reports of mast cells in the wall of the bladder. Mast cells in general, contain granules of histamine and when they are released, will cause inflammation.
My clinical veterinary studies for the past 50 years, have revealed that those canines and felines that have IBS and bladder inflammations also have something in common. What they all have in common, is an IgA deficiency. For information on this subject, please read The Endocrine Regulation of IGA and Townsend Letter for Doctors and Patients, November 2005.
IgA is the mucous membrane antibody protector for all the mucous membranes in the body.
When the IgA is deficient, disease may occur at any of the areas that should be protected by this antibody.
When there is a deficiency of this antibody, whether predetermined by genetics, acquired with age, or adverse environmental input, a disease may occur.
If the IgA level is deficient, it may make it easier to understand why disease of the bowel and the bladder can all be associated.
For all of you humans and pet owners, please realize that your diseases may be caused by an IgA deficiency which not only includes IBS and bladder inflammation, but all those other areas that are also not protected.
In animals, an IgA deficiency may be easily identified by a gingival flare.
What is a gingival flare? This is a red, inflammatory line that occurs at the point where the gum tissue reflects upon the enamel of the teeth.
A portion of the mouth or the entire mouth may be involved and is then referred to as stomatitis.
In humans, an IgA imbalance will manifest itself as a chronic gum problem called periodontitis or a more involved stomatitis.
In both humans and animals, cleaning the teeth will not stop gum loss unless the IgA deficiency is corrected.
Please think about the IgA in the lungs. If the IgA is deficient, it will cause asthma, and possibly cystic fibrosis, including inhalant allergies.
Joints also contain IgA, and when there is a deficiency, you can now see why an unprotected joint might develop inflammation with accompanying arthritis.
Chronic disease of the kidneys also come from a deficient IgA and an inability to stop chronic bacterial infections.
For humans and animals, most food allergies and sensitivities come from an IgA deficiency, including insect sensitivities and vaccine reactions.
A simple food or supplement can cause an adverse intestinal and bladder reaction.
When this imbalance is present, an innocent vaccine may cause catastrophic reactions in the human or in the animals.
A simple bee sting may become be catastrophic for a human or animals with an IgA deficiency.
In a child or young animal with an IgA deficiency, when vaccinated, the end effect of this IgA imbalance may cause catastrophic impacts on the recipient.
It is also not recognized in humans and animals, when the IgA level is below a certain point, oral hormonal supplementation and medication will not be absorbed.
Chronic allergies, autoimmunity and cancer, all include an IgA imbalance.
Have you ever checked your child or your pet for their IgA level?
The IgA deficiency is merely an effect of the cause of most chronic diseases in humans and in animals. If it is measured, there is very little understanding of what an IgA deficiency means.
An IgA deficiency occurs because of a deregulation of the B- lymphocyte.
How does this happen? It happens because of a cortisol imbalance in the patient.
The fact that the patient’s cortisol levels have been measured at every 4 to 6 hours through a 24 hour period, does not tell the heath care professional that a normal cortisol sequence can be used by the body.
24 hour urine tests and salivary tests may indicate how much free hormone the patient may be producing, but it does not indicate if that free hormone is available to work in the body of the patient.
It is important for the medical world to realize this and also realize that the endocrine system regulates the immune system.
Let’s now get back to why a human or animal may develop an IgA deficiency.
An IgA deficiency comes from a hormonal dysfunction that leads to a B- lymphocyte deficiency.
How does this occur?
The deficiency in IgA develops from a cortisol imbalance.
The patient’s cortisol may be deficient or normal and elevated and still be inactive.
Without actually checking the end affects of what any hormone levels may be, no one can tell you if that hormone can actually be used in the body and is of value.
To determine this, the following test that needs to be done for you and your pet is as follows:
- Total estrogen
- Total T3
- Total T4
The IgA level will be depressed when the cortisol level from the middle layer adrenal cortex is deficient or is normal or elevated and is inactive.
When this occurs, the negative feedback mechanism to the hypothalamic-pituitary axis will not be hormonally funded correctly.
Also, when this occurs, the hypothalamic pituitary axis will continue to produce the hormone from the pituitary gland called ACTH.
When this occurs and the cortisol imbalance cannot respond to this negative feedback mechanism, the inner layer adrenal cortex does respond in a direct feedback mechanism producing elevated amounts of adrenal estrogen and androgen.
The increased levels of adrenal estrogen deregulate the immune system, including the B-Lymphocyte and its production of IgA.
Many other imbalances also occur with the T-Lymphocyte, which I discuss in other articles on my website.
The purpose of this article is to show you the various systems that can be affected by an IgA imbalance.
And no, the medical profession does not know why patients that have IBS also have interstitial cystitis.
Hopefully my clinical findings will help MD’s and DVM’s, to better understand their patients’ imbalances and a better way to treat their effects.
Dr. Al Plechner